The Faculty of Medicine and Surgery incorporates Physiology, Biochemistry, Anatomy, Clinical Pharmacology and more and is responsible for all the teaching and training of medical students at Imo State University. These departments are sited both at the main campus and the Orlu campus. Practical are housed at Imo State Teaching Hospital at Orlu.
The Faculty offers the four-year Doctor of Medicine (M.D.) degree, a comprehensive professional academic program which combines lectures, case analyses, and practical exercises. The entire curriculum focuses on the basic, clinical, and emergency medical sciences. Teaching methods make use of both classic and modern medical practices and technologies.